Inhalation Toxicology
The administration by inhalation is an elegant way to administer medications to the respiratory system if local administration is desired. In other cases, fast systemic administration can be achieved without passing through the digestive tract and being affected by the liver. In preclinical development, many different systems are available; for example, rotating brush generators are used for powder inhalation, while air jets or vibrating mesh nebulizers are employed to produce aerosols for liquid formulations. In contrast, metered dose inhalers are available for powder and liquid formulations.