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Inhalation Toxicology

The administration by inhalation is an elegant way to administer medications to the respiratory system if local administration is desired. In other cases, fast systemic administration can be achieved without passing through the digestive tract and being affected by the liver. In preclinical development, many different systems are available; for example, rotating brush generators are used for powder inhalation, while air jets or vibrating mesh nebulizers are employed to produce aerosols for liquid formulations. In contrast, metered dose inhalers are available for powder and liquid formulations.

inhilation toxicology challenges

Challenges in Inhalation Toxicology

Because our team has been in the industry for so long, we understand that inhalation toxicology programs have many challenges. The following roadblocks are frequently encountered during the non-clinical development of inhaled medications:

  • Usually, deep lung administration of medication has to be achieved.
  • Physicochemical properties of the molecules, such as particle size and shape, charge, and susceptibility to shear forces, may impede the generation of a suitable aerosol.
  • Inhalation toxicology requires large amounts of the drug product.
  • Pulmonary pharmacokinetic processes can be complex
  • Experienced technicians are required
  • In the clinic and commercialization, the appropriate use of the inhaler is critical
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Here to Help Your Inhalation Program Succeed

With over 50 years of combined hands-on experience in troubleshooting technical issues with inhalation systems, we are there to help:

  • In-depth knowledge of the different inhalation systems
  • Early evaluation of aerosol generation to ensure that technical issues are addressed promptly.
  • Two experienced inhalation toxicologists in our team support your development needs.
  • Experts support different product formulations (e.g., carriers, lubricants, micronization) or changing the structure of the particles using modified supercritical anti-solvent technologies.
  • A network of prequalified CROs with inhalation capabilities and experienced study directors and technicians.
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inhilation toxicology consultants

Team Member Highlight

Meet a Couple of Our Toxicology Experts

Dominic Poulin

KreaMedica’s Senior Preclinical Toxicologist.

With over 20 years of experience in the preclinical CRO industry, from hands-on technician to study director, his first years were solely devoted to inhalation, later increasing his portfolio to include all general routes of administration, in vivo pharmacology animal models, and client management.  His experience to inhalation troubleshooting and knowledge of CRO and regulatory expectations will be a great asset to your team.

Mathew Reed

KreaMedica’s Senior Preclinical Toxicologist.

With over 20 years of experience in the preclinical CRO industry, from hands-on technician to study director, his first years were solely devoted to inhalation, later increasing his portfolio to include all general routes of administration, in vivo pharmacology animal models, and client management.  His experience to inhalation troubleshooting and knowledge of CRO and regulatory expectations will be a great asset to your team.

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